Appetite Stimulants for Cats 🍽️🐾

When a cat stops eating, it’s more than just a concern—it can quickly become a medical emergency. Unlike dogs, cats’ bodies aren’t designed to handle prolonged fasting, and even 48 hours without food can lead to hepatic lipidosis (fatty liver disease). If your cat is losing weight or showing little interest in food, appetite stimulants may be necessary to kick-start their hunger while treating the underlying issue.

In the USA, veterinarians rely on FDA-approved appetite stimulants and off-label options to help cats regain their appetite safely. Below, we’ll break down the best choices, how they work, and what cat owners should know before using them.


🍽️ Key Takeaways: Quick Answers for Cat Owners

QuestionQuick Answer
What’s the best appetite stimulant for cats?Mirtazapine (Mirataz) – Fast-acting, easy-to-use transdermal gel.
Which appetite stimulant is best for kidney disease cats?Capromorelin (Elura) – Mimics the hunger hormone and is kidney-safe.
Can antihistamines help increase appetite?Yes, Cyproheptadine is an antihistamine that also boosts hunger.
What if my cat is nauseous and won’t eat?Maropitant (Cerenia) – Helps with nausea, which can indirectly boost appetite.
Are there natural appetite stimulants?Yes, warming food, adding broth/tuna juice, and using catnip may help.
How long do appetite stimulants take to work?Mirtazapine (Mirataz) works within 24 hours, Capromorelin within 1-2 days.
Do these require a prescription?Yes, except for natural options like catnip and warmed food.

💊 What Are the Best Appetite Stimulants for Cats?

When choosing an appetite stimulant, vets consider the cause of appetite loss, the cat’s health condition, and ease of administration. Here’s a breakdown of the top options:

1️⃣ Mirtazapine (Mirataz) – The Gold Standard

What It IsFDA-approved antidepressant used in cats to stimulate appetite and reduce nausea.
How It WorksIncreases serotonin levels and blocks appetite-suppressing receptors in the brain.
Best For… ✅Most common appetite loss cases, older cats, cats who are hard to pill.
How It’s GivenTransdermal gel (rubbed inside the ear) or oral tablet.
Time to Take EffectWithin 24 hours, peak effect at 48 hours.
Common Side Effects ⚠️Vocalization, hyperactivity, mild agitation (dose-dependent).

👉 Why It’s Popular: Easy to administer (gel form) & quick results. FDA-approved for weight loss in cats.


2️⃣ Cyproheptadine – The Budget-Friendly Backup

What It IsAn antihistamine that also stimulates appetite by altering serotonin levels.
How It WorksReduces serotonin’s effect on appetite control, making food seem more appealing.
Best For… ✅Cats who need long-term appetite stimulation, cats with allergies.
How It’s GivenTablet or compounded liquid (flavored tuna/chicken).
Time to Take EffectTakes 1-2 days to see a full effect.
Common Side Effects ⚠️Drowsiness, mild hyperactivity, dry mouth.

👉 Why Some Vets Prefer It: Cheaper than Mirtazapine & well-tolerated.


3️⃣ Capromorelin (Elura) – Best for Kidney Disease Cats

What It IsA liquid appetite stimulant that mimics ghrelin (the “hunger hormone”).
How It WorksTriggers hunger signals in the brain and helps older cats maintain weight.
Best For… ✅Cats with chronic kidney disease (CKD) or long-term appetite loss.
How It’s GivenOral liquid (2 mg/kg daily).
Time to Take Effect1-2 days.
Common Side Effects ⚠️Vomiting, lethargy in some cats.

👉 Why It’s Unique: FDA-approved for cats with CKD. Safe for long-term use.

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4️⃣ Maropitant (Cerenia) – The Nausea Fixer

What It IsAn anti-nausea medication that helps cats feel well enough to eat.
How It WorksBlocks substance P, a brain chemical that triggers vomiting and nausea.
Best For… ✅Post-surgery, illness recovery, kidney disease, chemotherapy.
How It’s GivenTablet or injection.
Time to Take EffectWithin 1-2 hours.
Common Side Effects ⚠️Drooling, lethargy (rare).

👉 Why It’s Useful: Not a direct appetite stimulant but helps cats eat by stopping nausea.


🌿 Natural Appetite Stimulants for Cats

For mild appetite loss or picky eaters, natural methods may help.

MethodHow It Helps ✅Best For… 🐾
Warming up wet foodEnhances the aroma, making food more enticing.Senior cats, mild appetite loss.
Adding tuna juice or brothBoosts flavor and smell (low-sodium only).Picky eaters, post-surgery recovery.
Catnip or SilvervineStimulates brain pleasure receptors, sometimes sparking hunger.Cats who respond to catnip (~50%).
Rotating food flavorsPrevents food boredom.Cats refusing their usual diet.

👉 When to Use: Natural methods work best for picky eaters but are not strong enough for medical appetite loss.


⏳ How Fast Do Appetite Stimulants Work?

MedicationTime to Start Working ⏰Peak Effect 📈Best For… ✅
Mirtazapine (Mirataz)24 hours48 hoursGeneral appetite loss.
Cyproheptadine1-2 days2-3 daysLong-term stimulation.
Capromorelin (Elura)1-2 daysOngoing with daily use.Kidney disease, chronic weight loss.
Cerenia (Maropitant)1-2 hoursSame dayNausea-related appetite loss.

👉 Key Insight: Mirtazapine is the fastest-acting appetite stimulant, while Capromorelin is best for long-term use.


🛑 When to See a Vet Immediately

🚨 If your cat hasn’t eaten for 24+ hours, contact your vet ASAP. Signs of severe problems include:

  • Rapid weight loss 🏥
  • Vomiting, diarrhea, or lethargy
  • Jaundice (yellow gums, skin) – a sign of hepatic lipidosis
  • Dehydration (skin tenting, dry gums)

Severe cases may require a feeding tube.


🏁 Final Thoughts: Which Appetite Stimulant is Best?

SituationBest Stimulant 💊Why It Works ✅
General appetite lossMirtazapine (Mirataz)Fast-acting & easy application (ear gel).
Kidney disease catsCapromorelin (Elura)Ghrelin-based, kidney-safe.
Cats who hate pillsMirtazapine (transdermal)No swallowing required.
Nausea-related appetite lossCereniaStops vomiting & nausea.
Long-term appetite issuesCyproheptadineBudget-friendly option.

💬 Have a cat who won’t eat? Drop your questions below, and our experts will help you find the best solution for your feline! 🐾💊

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🗨️ Expert Responses to Your Questions


💬 Comment 1: “My senior cat is losing weight but still eats a little. Should I still use an appetite stimulant?”

Yes—if your cat is eating but not maintaining weight, an appetite stimulant can help increase food intake and prevent malnutrition. Senior cats often experience reduced appetite due to aging, kidney disease, hyperthyroidism, or dental pain. Identifying the cause is key, but an appetite stimulant can support weight maintenance while underlying conditions are managed.

🐾 Best Appetite Stimulants for Senior Cats

MedicationWhy It’s Helpful? 🏆Best For… ✅Common Side Effects ⚠️
Mirtazapine (Mirataz)Boosts appetite & reduces nauseaGeneral weight loss, senior catsVocalization, mild hyperactivity
Capromorelin (Elura)Mimics hunger hormone ghrelinKidney disease-related weight lossOccasional vomiting
CyproheptadineStimulates appetite & has mild sedationCats with chronic appetite declineDrowsiness, dry mouth

👉 Expert Tip: If your senior cat loses more than 5-10% of their body weight, an appetite stimulant may be necessary to prevent further decline.


💬 Comment 2: “How do I know if my cat’s appetite loss is serious?”

Cats are notoriously good at hiding illness, so any significant decrease in appetite should be taken seriously. If your cat refuses food for more than 24 hours, seek veterinary care immediately.

🚨 Signs That Appetite Loss Is a Medical Emergency

SymptomWhat It Might Mean? 🤔Action to Take 🚑
Not eating for 24+ hoursRisk of hepatic lipidosis (fatty liver disease)Vet visit ASAP
Sudden weight lossMetabolic disorder, kidney disease, hyperthyroidismSchedule bloodwork
Vomiting, diarrhea, lethargyUnderlying illness or toxin exposureEmergency vet if severe
Drooling or pawing at mouthDental pain, oral infection, nauseaDental exam needed
Hiding, avoiding food bowlStress, anxiety, or illnessAssess home environment, vet check-up

👉 Expert Tip: Weight your cat weekly—unexplained weight loss over time can indicate an underlying health issue even if your cat is still eating.


💬 Comment 3: “Is Mirataz better than other appetite stimulants?”

Mirataz (mirtazapine) is often the first choice for appetite stimulation in cats because it is FDA-approved, fast-acting, and available as a transdermal gel—making it easier to administer than pills. However, other appetite stimulants may be a better fit depending on your cat’s condition.

💊 Mirataz vs. Other Appetite Stimulants

MedicationBest For… ✅How It’s Given 🏆Works Within ⏳
Mirtazapine (Mirataz/Miravastin)General appetite loss, nausea reductionTransdermal gel or tablet24 hours
Capromorelin (Elura)Cats with kidney disease, long-term weight lossOral liquid1-2 days
CyproheptadineCats who need long-term appetite supportTablet or liquid1-2 days

👉 Expert Tip: Mirataz is the most commonly prescribed option due to its ease of use and quick action, but for cats with kidney disease, Capromorelin may be the better long-term choice.

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💬 Comment 4: “Can I use a natural appetite stimulant instead of medication?”

Natural appetite stimulants can help for mild appetite loss but are not strong enough for medical conditions or severe anorexia. They are best used as supportive measures alongside veterinary treatment.

🌿 Natural Appetite Stimulants & How They Help

Natural MethodWhy It Works ✅Best For… 🐱
Warming up wet foodEnhances scent, making food more appealing.Picky eaters, senior cats.
Adding bone broth or tuna juiceBoosts flavor and hydration.Cats recovering from illness.
Sprinkling nutritional yeast or parmesanAdds a savory umami taste.Cats who refuse dry food.
Offering hand-feeding or syringe feedingEncourages eating through interaction.Cats recovering from surgery.

👉 Expert Tip: Natural methods work best when combined with a prescription appetite stimulant if the appetite loss is severe.


💬 Comment 5: “Can an appetite stimulant be used long-term?”

Yes, but it depends on the specific medication and underlying health condition. Some stimulants are safer for extended use than others.

⏳ Safe Long-Term Appetite Stimulants for Cats

MedicationSafe for Long-Term Use? ✅Best For… 🏆Common Concerns ⚠️
Mirtazapine (Mirataz)Yes, but monitor for agitation.General appetite loss.Hyperactivity in some cats.
Capromorelin (Elura)Yes, FDA-approved for long-term use.Chronic kidney disease.Occasional vomiting.
CyproheptadineYes, but with vet oversight.Cats with long-term low appetite.Drowsiness at higher doses.

👉 Expert Tip: For chronic conditions (CKD, cancer, senior weight loss), Capromorelin is often preferred for long-term appetite stimulation.


💬 Comment 6: “What’s the best way to give my cat an appetite stimulant?”

The method of administration depends on what your cat tolerates best. If your cat refuses pills, consider transdermal gel (Mirataz) or flavored compounded liquids.

🖐️ Easiest Ways to Give Appetite Stimulants

MethodBest Medications for This Method ✅Why It Works 🏆
Transdermal Gel (Rub on Ear)Mirtazapine (Mirataz)No need to pill or force-feed.
Flavored Liquid (Oral Syringe)Capromorelin (Elura), CyproheptadineEasier for picky eaters.
Crushed Tablet in FoodCyproheptadineWorks if cat eats willingly.
Syringe-Feeding Wet Food + MedsAny liquid stimulantGood for sick cats.

👉 Expert Tip: If your cat hates oral meds, Mirataz (ear gel) is the easiest option!


💬 Comment 7: “Are there any risks to using appetite stimulants?”

Most appetite stimulants are safe when used correctly, but side effects can occur, especially at higher doses. Always follow your vet’s dosing instructions carefully.

⚠️ Common Side Effects of Appetite Stimulants

MedicationPossible Side Effects ⚠️How to Reduce Risk ✅
Mirtazapine (Mirataz)Vocalization, hyperactivity, mild tremors.Use the lowest effective dose.
Capromorelin (Elura)Vomiting, lethargy.Give with food if nausea occurs.
CyproheptadineDrowsiness, dry mouth.Adjust dose based on tolerance.

👉 Expert Tip: If your cat experiences severe side effects, stop the medication and consult your vet immediately.


💬 Comment 8: “How long should I use an appetite stimulant for my cat?”

The duration of appetite stimulant use depends on the cause of the appetite loss and how well your cat responds to treatment. Some cats only need it for a few days to recover from illness, while others with chronic conditions may require long-term support.

⏳ How Long Should You Use an Appetite Stimulant?

SituationRecommended Duration ⏰Best Stimulant for This Case 💊Vet Monitoring Needed? 🏥
Post-surgery recovery3-7 daysMirtazapine (Mirataz), Capromorelin (Elura)Minimal, unless complications arise.
Temporary illness (infection, GI upset)1-2 weeksMirtazapine, CyproheptadineReassess after 1 week.
Chronic kidney disease (CKD)Ongoing, as neededCapromorelin (Elura)Regular kidney function tests.
Cancer-related weight lossLong-term useMirtazapine, CapromorelinMonitor weight & hydration.
Senior cat with ongoing low appetiteLong-term, intermittentMirtazapine, CyproheptadineAdjust dose based on appetite.

👉 Expert Tip: For chronic conditions, appetite stimulants should be used alongside supportive care like hydration therapy and high-calorie diets.


💬 Comment 9: “Can I give my cat an appetite stimulant if they have diabetes?”

Yes, but caution is needed. Some appetite stimulants can affect blood sugar levels, making diabetes management more challenging. Always consult your vet before using one.

🩸 Best Appetite Stimulants for Diabetic Cats

MedicationSafe for Diabetic Cats? ✅ / ⚠️Why or Why Not? 🤔
Mirtazapine (Mirataz)Generally safeDoes not significantly affect insulin regulation.
Capromorelin (Elura)⚠️ Use with cautionMay increase blood sugar levels in some cases.
CyproheptadineSafer optionNo known impact on blood glucose.

👉 Expert Tip: If using an appetite stimulant for a diabetic cat, monitor their blood sugar levels closely to ensure stability.


💬 Comment 10: “Can an appetite stimulant help my cat eat a prescription diet they don’t like?”

Yes! Many prescription diets are bland and unfamiliar, so cats may resist eating them. Appetite stimulants can encourage eating, but flavor enhancers and gradual diet transitions also help.

🐾 Tips to Get Your Cat to Eat Prescription Food

StrategyWhy It Works? ✅Best For… 🏆
Mixing with favorite wet foodGradually introduces the new flavor.Cats switching to kidney or weight-loss diets.
Warming the food slightlyEnhances aroma, making it more appealing.Picky eaters, senior cats.
Using Mirtazapine or CapromorelinIncreases hunger, making diet transition easier.Cats refusing prescription diets.
Adding low-sodium tuna juiceImproves taste without harming diet benefits.Cats rejecting new food.

👉 Expert Tip: Gradually transition over 7-10 days by mixing small amounts of the prescription food with their regular food.


💬 Comment 11: “My cat started eating but isn’t gaining weight—why?”

Eating doesn’t always mean your cat is consuming enough calories. If your cat is losing or maintaining weight despite eating, they may need a calorie-dense diet or additional veterinary evaluation.

📉 Why Your Cat May Not Be Gaining Weight

Possible CauseWhy It Happens? 🤔Solution ✅
Not eating enough caloriesFood intake increased but still too low.Offer high-calorie diets (Hill’s a/d, Royal Canin Recovery).
Increased metabolism (Hyperthyroidism, Diabetes)Body burns calories too quickly.Check thyroid & blood sugar levels.
Malabsorption (IBD, GI disease)Food is eaten but nutrients aren’t absorbed.Vet evaluation, possible diet change.
Cancer or Chronic DiseaseBody loses weight despite eating.Comprehensive vet workup.

👉 Expert Tip: Track your cat’s weight weekly—if they’re not gaining after 2 weeks of appetite stimulation, further medical investigation is needed.


💬 Comment 12: “Are there any over-the-counter appetite stimulants I can buy?”

Most effective appetite stimulants require a prescription, but some over-the-counter options may help mild cases of appetite loss.

🛍️ Over-the-Counter Appetite Stimulants for Cats

ProductHow It Helps ✅Best For… 🐾
FortiFlora (Probiotic)Contains enticing liver flavor & gut health benefits.Cats with mild appetite loss, GI upset.
Nutri-Cal (High-Calorie Gel)Tasty, calorie-rich supplement.Underweight cats needing extra calories.
Catnip or SilvervineStimulates excitement, may trigger eating.Picky eaters.
Bone broth (low sodium)Enhances food flavor and smell.Senior cats, mild appetite loss.

👉 Expert Tip: OTC options work best for finicky eaters but are not strong enough for medically serious appetite loss—prescription stimulants are far more effective.


💬 Comment 13: “Can I use an appetite stimulant for a kitten that isn’t eating?”

Extreme caution is needed when using appetite stimulants in kittens. If a kitten isn’t eating, the priority is determining why and ensuring they get proper nutrition.

🐱 Safe vs. Unsafe Appetite Stimulants for Kittens

MedicationSafe for Kittens? ✅ / ❌Why? 🤔
Mirtazapine (Mirataz)⚠️ Use only under vet supervision.May cause excessive sedation in young kittens.
Capromorelin (Elura)Not tested for kittens under 4 months.May cause vomiting, lethargy.
Nutri-Cal (OTC high-calorie gel)Safer option.Helps provide calories while encouraging eating.

👉 Expert Tip: Kittens under 8 weeks must eat frequently—if they’re not, syringe feeding or veterinary intervention is needed immediately.


💬 Comment 14: “How do I know if my cat is eating enough?”

A cat’s daily caloric needs depend on age, weight, and health. Appetite stimulants increase food intake, but tracking is essential to ensure they are eating enough to maintain or gain weight.

🍽️ How Many Calories Does Your Cat Need?

Cat’s WeightCalories Per Day (Maintenance) 🔢Calories for Weight Gain 📈
8 lbs (3.6 kg)180-200 kcal/day220-250 kcal/day
10 lbs (4.5 kg)200-230 kcal/day250-300 kcal/day
12 lbs (5.4 kg)230-260 kcal/day280-320 kcal/day

👉 Expert Tip: Weigh your cat weekly—if they’re not gaining weight, they may need more food, a diet change, or a vet check-up.


💬 Comment 15: “Why does my cat start eating and then stop after a few bites?”

This behavior—starting to eat but stopping after a few bites—can indicate several underlying causes. Cats are instinctively cautious eaters, but when this happens regularly, it could be a sign of nausea, dental pain, or food aversion.

🔍 Common Reasons Cats Stop Eating Mid-Meal

Possible CauseWhy It Happens? 🤔How to Fix It ✅
Nausea (Silent or Obvious) 🤢Food smells good, but the cat feels sick when eating.Try Cerenia (Maropitant) for nausea relief.
Dental Pain or Mouth Issues 🦷Tooth decay, gingivitis, or resorptive lesions cause discomfort.Vet dental exam, soft food, pain relief if needed.
Food AversionIf the cat had a bad experience with a certain food (e.g., vomiting), they may associate it with feeling unwell.Offer a new protein or brand, use appetite stimulants.
Gastrointestinal Upset (IBD, Pancreatitis) 🏥Eating triggers discomfort, so they stop.Vet check for GI conditions, switch to an easily digestible diet.
Stress or Environmental Factors 🏡Something in the surroundings (loud noises, other pets, dirty bowl) makes eating stressful.Create a quiet, stress-free feeding area.

👉 Expert Tip: If your cat consistently stops eating mid-meal, track their patterns, food types, and any signs of nausea—and consult a vet to rule out medical causes.


💬 Comment 16: “Can I use appetite stimulants for a cat recovering from surgery?”

Yes, appetite stimulants are commonly used in post-surgical recovery, especially if pain, nausea, or stress is reducing food intake. However, not all stimulants are safe immediately after surgery, so consult your vet first.

🩺 Best Appetite Stimulants for Post-Surgery Cats

MedicationWhy It’s Helpful? 🏥Best For… ✅When to Use? ⏳
Mirtazapine (Mirataz)Boosts appetite while reducing nausea.Most post-surgical recovery cases.24-48 hours after surgery.
Capromorelin (Elura)Mimics hunger hormone, encouraging eating.Weak, recovering cats needing weight gain.Once the cat is stable.
Cerenia (Maropitant)Stops nausea and vomiting.Cats refusing food due to nausea post-anesthesia.Immediately if nausea is present.

👉 Expert Tip: After surgery, pain control (e.g., Buprenorphine) should also be managed, as discomfort can reduce appetite significantly.


💬 Comment 17: “Can appetite stimulants cause hyperactivity or agitation in cats?”

Yes, some cats experience increased energy, vocalization, or even mild agitation after taking appetite stimulants—especially Mirtazapine (Mirataz).

⚡ Appetite Stimulants & Hyperactivity: What to Expect

MedicationCan It Cause Hyperactivity? 🚀Why It Happens? 🤔How to Reduce It ✅
Mirtazapine (Mirataz)⚠️ Yes, in some cats.Increases serotonin, which can heighten vocalization or restlessness.Use a lower dose (e.g., every other day).
Capromorelin (Elura)Rarely.Works by mimicking hunger hormones, no major stimulant effect.Safe for long-term use.
Cyproheptadine⚠️ Mild hyperactivity in some cases.Alters serotonin pathways, sometimes causing mild stimulation.Reduce dose if excessive.

👉 Expert Tip: If your cat seems hyperactive or restless after using an appetite stimulant, consult your vet about adjusting the dosage or trying a different medication.


💬 Comment 18: “My cat is eating again—should I stop the appetite stimulant?”

If your cat has regained appetite and is eating consistently, you may be able to taper off the stimulant—but this depends on the underlying condition.

🔄 When to Stop vs. Continue Appetite Stimulants

SituationShould You Stop the Medication? ✅/❌How to Wean Off? ⏳
Post-illness recovery (infection, temporary stress)Yes, once appetite is stable.Reduce dose gradually over several days.
Kidney disease or chronic conditionsNo, continued use may be needed.Keep using long-term if weight loss is a concern.
Surgery or temporary medical treatmentOnce full recovery is confirmed.Monitor for appetite relapse.
Senior cats with age-related weight loss⚠️ May need intermittent use.Adjust based on weight trends.

👉 Expert Tip: If appetite drops again after stopping the stimulant, long-term support may be needed to prevent weight loss.


💬 Comment 19: “Can I use appetite stimulants for a cat on chemotherapy?”

Yes, appetite stimulants can be a crucial part of supportive care for cats undergoing chemotherapy, as treatments like prednisolone, chlorambucil, or doxorubicin can cause nausea and weight loss.

🧑‍⚕️ Best Appetite Stimulants for Cats on Chemotherapy

MedicationWhy It’s Helpful? 🏆Best For… ✅Common Side Effects ⚠️
Mirtazapine (Mirataz)Boosts appetite while reducing nausea.General appetite loss from chemotherapy.Mild vocalization, hyperactivity.
Cerenia (Maropitant)Blocks nausea receptors, improving appetite.Cats experiencing vomiting from chemo.Occasional lethargy.
Capromorelin (Elura)Increases hunger drive, maintaining weight.Long-term chemo patients.Occasional vomiting.

👉 Expert Tip: Combining Cerenia with an appetite stimulant is often the best approach for chemo-related nausea and appetite loss.


💬 Comment 20: “What is the safest appetite stimulant for long-term use?”

For long-term use, safety and tolerability are key—some medications are better suited for ongoing support than others.

🏆 Safest Appetite Stimulants for Long-Term Use

MedicationSafe for Long-Term? ✅/❌Why or Why Not? 🤔
Mirtazapine (Mirataz)Generally safe, but dose should be monitored.Can be used long-term, but some cats develop mild agitation.
Capromorelin (Elura)FDA-approved for chronic use.Designed for long-term appetite support in kidney disease.
CyproheptadineGood for intermittent long-term use.Can be used off-label for chronic cases.

👉 Expert Tip: For cats needing lifelong appetite support (e.g., kidney disease, cancer, or age-related weight loss), Capromorelin (Elura) is often the safest choice.

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